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Bromelain

Bromelain refers to a group of sulfur-containing enzymes that digest protein (proteolytic enzymes or proteases) obtained from the pineapple plant. Commercial bromelain is usually derived from the stem, which differs from the bromelain derived from the fruit. Commercial bromelain contains a mixture of several proteases and small amounts of several other enzymes, and organically bound calcium. Japan, Taiwan, and Hawaii are the major suppliers of commercial bromelain.

Bromelain Historical Use

A little more than 500 years ago Christopher Columbus discovered his first pineapple on the Caribbean island of Guadaloupe. He was intrigued not only by the fruit’s succulent flesh and aromatic juice, but also by the ways in which islanders claimed the plant could be used to heal. Bromelain was introduced as a therapeutic agent in 1957, and since that time more than 200 scientific papers on its therapeutic applications have appeared in medical literature. Many of the early studies were performed using Ananase (Rorer), an enteric-coated bromelain tablet. Later studies implied that bromelain failed in some of these early studies because of the enteric coating as well as inadequate dosages.

Bromelain Remedy For

The key uses of bromelain are the Favorable Effects of,

Problem due to lack of blood supply to heart muscles
Arthritis
Athletic injury
Bronchitis
Bruising
Burns
Cellulitis
Dysmenorrhea
Maldigestion
Pancreatitis
Pneumonia
Scleroderma
Sinusitis
Staph Problem created due to harmful organism
Swelling
Surgical trauma
Thrombophlebitis

Also, an adjunct in Long standing problems therapy.

Bromelain is quite effective as a substitute for trypsin or pepsin in cases of pancreatic insufficiency. Because of bromelain’s ability to remain active over a wide pH range, it can act on substrates in the stomach as well as in the small intestine.
Bromelain’s ability to reduce soreness has been documented is a variety of experimental models and clinical studies it has also shown to be as effective as antibiotics in treating a variety of infectious processes.
Bromelain exerts a number of unique antiLong standing problems effects. When added to the diet of mice with Long standing problems, bromelain (0.3% of the diet by weight) decreased lung metastases by 90%.
Bromelain is a natural blood thinner because it Beneficial Effectss excessive blood platelet stickiness. This may explain, in part, the positive reports in a few clinical trials of bromelain to decrease symptoms of Problem due to lack of blood supply to heart muscles and thrombophlebitis.

Drug Interactions

potentiates antibiotics by improving response to these a substance used in managing discoforts in treating a variety of Problem created due to harmful organisms (PO in human clinical trial)208

Bromelain Active Constituents

Bromelain (EC 3.4.22.4) is the genuine mixture of bromelain A and B, the proteolytic enzymes of pineapple fruit. The activity of bromelain is expressed in a variety of enzyme units. The Food Chemistry Codex (FCC) officially recognizes the use of milk clotting units (mcu). The gelatin-digesting unit is another enzyme unit that is acceptable and equal in numerical value to the milk-clotting unit. Different grades of bromelain are available on the basis of the milk- clotting unit. For most indications the recommended milk clotting unit range is 1,200 to 1,800.

Bromelain Typical Dosage

Unless otherwise prescribed, 80 – 320 mg of bromelain (200–800) FIP units) in 2 or 3 doses. Unless being used as a digestive aid, administration of bromelain should be made on an empty stomach. Dosage depends on the potency of the preparation.

Bromelain Side Effects

An increased tendency for bleeding in the case of simultaneous administration of anticoagulants and inhibitors of thrombocytic aggregation cannot be excluded. The levels of tetracyclines in plasma and urine are increased by simultaneous intake of bromelain. “Although no significant side effects have been noted, allergic reactions may occur. Other possible but unconfirmed reactions include nausea, vomiting, diarrhea, metrorrhagia, and menorrhagia.