Give Vita-Treat pet calm to your pet about 20 to 30 minutes prior to periods of stress. If stressful situations continue, another dosage may be given in 4 to 6 hours. Suggested use for dogs & cats: Toy...3-24lbs...1/2 tablet, Small/medium...25-50lbs...1 tablet, Large...51-100lbs...2 tablets, Giant...101+lbs...3 tablets.